Tag Archives: 爱上海

March 1, 2021

Writing the book of cancer knowledge

first_imgThe goal of cancer treatment is to match the right drug to the right target in the right patient. But before such “personalized” drugs can be developed, more knowledge is needed about specific genomic alterations in cancers and their sensitivity to potential therapeutic agents.Now an academic-industry collaboration is releasing the first results from a new and freely available resource that marries deeply detailed cancer genome data with predictors of drug response, information that could lead to refinements in cancer clinical trials and future treatments. The Cancer Cell Line Encyclopedia (CCLE), authored by scientists at the Broad Institute of Harvard and MIT, Harvard-affiliated Dana-Farber Cancer Institute, the Genomics Institute of the Novartis Foundation, and the Novartis Institutes for Biomedical Research, is described in the March 29 issue of the journal Nature. In a proof of principle, the researchers also report that genomic predictors of drug sensitivity revealed three novel candidate biomarkers of response.“We hope that the Cancer Cell Line Encyclopedia will be a preclinical resource that could guide clinical trials,” said Levi A. Garraway, a senior associate member of the Broad Institute, an associate professor at Harvard Medical School and Dana-Farber Cancer Institute, and a co-corresponding author of the paper.“The CCLE is a public resource that we think will catalyze discoveries throughout the cancer research community,” said Todd Golub, director of the Broad’s Cancer Program, Charles A. Dana Investigator in Human Cancer Genetics at the Dana-Farber Cancer Institute, and a co-author of the paper. “With this initial effort, we have taken some critical first steps. The challenge now is to greatly expand the number of compounds tested across the panel of cell lines.”The CCLE integrates gene expression, chromosomal copy number, and massively parallel sequencing data from almost 1,000 human cancer cell lines together with pharmacological profiles for 24 anticancer drugs across roughly half of these cell lines. The scale of the project allows greater depth of genetic characterization and pharmacological annotation than previously possible with fewer cell lines. A separate effort by scientists at Harvard-affiliated Massachusetts General Hospital and the Sanger Institute appears in the same issue of Nature.To accomplish such a feat, the team of scientists relied on the genetics, computational biology, and drug-screening capabilities at the Broad, Dana-Farber, and Novartis. They chose 947 of the nearly 1,200 commercially available cancer cell lines to reflect the genomic diversity of human cancers.“One of the strengths of the CCLE lies in the number of cell lines it surveys,” said Nicolas Stransky, a computational biologist in the Cancer Program at the Broad and a co-first author of the paper. “We can focus on rare cancer subtypes and still have sufficient statistical power for analyses.”Cancer cell lines are malignant cells that have been removed from tumor tissue and cultured in the laboratory. Under controlled conditions, they can grow indefinitely.  This near-immortality is an advantage for performing repeated experiments, but it can be a potential pitfall if the cells differ markedly from tumors because they lack typical surroundings. However, with relatively few exceptions, the CCLE cell lines proved to be representative genetic proxies for primary tumor subsets across multiple different cancer types.Correlating the more than 50,000 genetic and molecular features that emerged from these cell lines created a computational challenge that the scientists met by adapting algorithms to the biological data. They tested this tool against genetic alterations known to predict sensitivity to cancer drugs, and confirmed the value of their systematic approach. Then they applied the predictive modeling methodology to genetic subtypes of cancer known to pose challenges for current treatment modalities.Armed with this kind of knowledge from the CCLE, researchers may have a much clearer idea of which tumors are most likely to respond to particular drugs before using them in clinical trials, the scientists say. Patients could therefore be selected for such studies based on how likely they are to respond, given the genetic and molecular makeup of their cancers.“We can ask questions not only about emerging targeted therapies, but also about standard chemotherapy drugs,” Garraway said.  “There may be ways to identify patients who are more likely to respond to conventional chemotherapy versus those who might not. The predicted ‘non-responders’ may be better off trying a different regimen.”There are more volumes to be written in this encyclopedia.“From a computational biology perspective, it’s a clean, complex data set that allows many more analyses,” Stransky said. “We are only scratching the surface of what can be done.”The Cancer Cell Line Encyclopedia project was enabled by a grant from the Novartis Institutes for Biomedical Research. Additional funding support was provided by the National Cancer Institute, the Starr Cancer Consortium, and the NIH Director’s New Innovator Award.last_img read more

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September 24, 2020

Juventus set asking price for Ronaldo as PSG consider move

first_img FacebookTwitterWhatsAppEmail分享 Cristiano Ronaldo is no longer considered ‘untouchable’ at Juventus and the Italian champions would consider selling him this summer for offers of £54m and above. The 35-year-old has enjoyed two fantastic seasons in Turin, scoring 65 goals in 89 appearances across all competitions, winning two Serie A titles in the process. However, there is set to be a substantial revamp at Juve this summer after a disappointing exit from the Champions League at the last 16 stage to Lyon. Maurizio Sarri has been replaced as manager by Andrea Pirlo and there is likely to be something of an overhaul of an ageing squad, with no player now deemed ‘untouchable’ by the Italian champions. The Parisians take on RB Leipzig in the semi-final on Tuesday evening and will be hoping to contest the final against either Lyon or Bayern Munich on Sunday night. Reports suggest that Juve will not consider offers of less than €60m (£54m) but that price tag may well not put off the Ligue 1 champions.Advertisement Promoted Content6 Major TV Characters We Were Relieved To See Leaving The ShowBest & Worst Celebrity Endorsed Games Ever Made20 Amazing Facts About The Daenerys Of The House Of Targaryen6 Ridiculous Health Myths That Are Actually True8 Most Expensive Mistakes The World Has Ever MadeWho Is The Most Powerful Woman On Earth?6 Extreme Facts About Hurricanes5 Of The World’s Most Unique Theme Parks12 Flicks That Almost Ended Their Stars’ Careers9 Facts You Should Know Before Getting A Tattoo10 Stargazing Locations To ‘Connect With Nature’2020 Tattoo Trends: Here’s What You’ll See This Year read also:VIDEO: Cristiano Ronaldo tries out diving in the sea on holiday The Portuguese superstar may well be attracted by the possibility of PSG, with the chance to conquer the fourth league, having won titles in England with Manchester United, Spain with Real Madrid, and now in Italy. Ronaldo has also been linked with a sensational move to Barcelona, where he could link-up with old for Lionel Messi and burn bridges with his former side in the Spanish capital. That switch seems fanciful, though, and is more a case that Juventus have been happy to offer him to any club that may take his salary, including Barca. Loading… last_img read more

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September 19, 2020

Beharry recommits to Green Machine

first_imgTHE Guyana Rugby Football Union (GRFU) will continue to reap the benefits of having Edward B. Beharry as one of its sponsors.The company yesterday handed over a sum of money to the union to aid the Green Machine in this year’s Rugby America’s North (RAN) Sevens Championship, billed for November 12-13 in Port of Spain, Trinidad.During a press briefing yesterday, Kamini Naresh, the company’s brand manager noted that the company was proud to continuously support the nation’s most successful outdoor sports team.She added that Beharry is committed to supporting the union and wished them well at the tournament. Marketing Manager, Satesh Singh, reminded the media that the company and rugby have forged a friendshipPresident of the union, Peter Green, reminded his charges that sponsorships such as Beharry’s must be rewarded with nothing less than excellence.The tournament will see Guyana with both men and women’s teams participating.For the men’s division, 14 nations have been listed with three in Pools A&B and four each in groups C&D. In pool A, Canada, Bermuda and the British Virgin Islands will battle, while pool B will have Mexico, St Vincent and the Grenadines and hosts Trinidad.Pool C will have The Cayman Islands, Barbados, Curacao and The Dominican Republic, while Guyana will take on Jamaica, the Turks and Caicos Islands and Martinique in pool D.On the distaff side, there are two pools of five teams each, with Canada, Jamaica, The Cayman Islands, Bermuda and the Turks and Caicos Islands in Pool A and Pool B featuring Mexico, Trinidad and Tobago, Guyana, The Bahamas and The Dominican Republic.(Stephan Sookram)last_img read more

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August 3, 2020

Mois, Norman lift Leafs past Rebels Friday at NDCC Arena

first_imgBy Bruce Fuhr The Nelson Daily Sports The Nelson Leafs continue to have success against the defending Kootenay Conference champion Castlegar Rebels. First star Max Mois and Brett Norman each had three points to lead the Leafs to a 6-2 victory over the Rebels Friday in Kootenay International Junior Hockey League action at the NDCC Arena. The win gives the Leafs the edge in the season series 3-2. The teams play the sixth game of the regular season series tonight in Castlegar. Game time is 7:30 p.m. Nelson scored twice in the opening period in a span of 15 seconds to put the Rebels on their heels. Mois and Colton Malmsten did the damage midway through the frame. After Anthony Delong cut the margin to 2-1 with a power play goal minutes into the second period, Nelson put the game away with three goals by Norman, Mois and Colton Schell. Nelson then rode the stellar netminding of Andrew Walton in the third to grab the win. Nelson’s Patrick Martens, continuing his point streak and Scott Morriseau on a Castlegar power play, completed the scoring. Martens has eight points in four games since returning to the Leafs after a stint in the BCHL with the Langley Rivermen. The Leafs out shot the Rebels 26-25.The loss is the second in a row for Castlegar while the Leafs have registered points in the last six games going 4-0-0-2.GAME NOTES: The game turned ugly with four seconds remaining when Castlegar goalie Jordan Gluck took exception to some crease crashing and was ejected from the game with a five-minute check-to-the-head penalty. A handful of players were sent to the showers by referee Shawn Peel with 10-minute misconducts. Castlegar back up Patrick Zubick was forced to replace Gluck in goal for the final four seconds. . . . Former Leaf Riley Henderson lasted just under half the game after being whistled for a checking from behind penalty. The Rebels picked up Henderson from Golden after being traded to the Rockets by the Leafs. . . .Castlegar fell to 11 points behind Murdoch leading Beaver Valley after the Hawks stopped Spokane 7-2 in the Lilac City. Ryan Edwards, Craig Martin and Nick Perez each had three points to lead the Hawks. . . .Thursday in the Boundary City, Spokane kept the Border Bruins winless at home with a 6-2 win. Five second-period goals sealed the deal for the [email protected]last_img read more

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August 2, 2020

STABLE NOTES BY ED GOLDEN – FRIDAY, FEB. 24, 2017

first_imgLuis Contreras849102111%48%$450,157 (Current Through Monday, Feb. 20) STEWART ELLIOTT WINS PRESTIGIOUS GEORGE WOOLF AWARDStewart Elliott, best known for his 2004 Kentucky Derby and Preakness Stakes wins aboard Smarty Jones, has been selected by a nationwide vote of his peers as winner of the 2017 George Woolf Memorial Jockey Award.A dominant force for many years in the Mid-Atlantic region, Elliott, 51, shifted his tack on a full-time basis to Southern California in 2016 and is now firmly established as one of the circuit’s top riders.“On behalf of our membership, I’m elated that Stewart has been selected as this year’s Woolf Award winner,” said Jockeys’ Guild National Manager Terry Meyocks. “Stewart is an exemplary example of what the George Woolf Award is all about. He’s not only a top rider, he’s a top human being as well and continues to be a solid role model for jockeys everywhere.  On behalf of the Guild, I congratulate him on a crowning achievement in his career.”One of the most highly coveted honors in all of American racing, the Woolf Award, which was named in honor of the legendary George “The Iceman” Woolf, can only be won once and was first presented by Santa Anita in 1950. The award, which honors riders whose careers and personal character earn esteem for the individual and the sport of Thoroughbred racing, was won last year by Victor Espinoza.              Born in Toronto, Canada, on March 11, 1965, Elliott has won more than 4,700 races and earned the respect of horsemen nationwide for his wide array of skills and consistent work ethic. Regarded as a strong finisher who is also an outstanding judge of pace, Elliott currently counts local trainers Bob Baffert, Kenny Black, Mike Puype, Art Sherman, Neil Drysdale, Mike Harrington, Jeff Bonde and many others among his regular clientele.“He’s just class through and through,” said Elliott’s agent, Craig Stephen. “He loves to work. He’s happiest when he’s on the back of a horse.”One of five Woolf finalists, Elliott outpolled contemporaries Kerwin Clark, Julien Leparoux, Glen Murphy and Scott Stevens to win this year’s edition. In becoming the 68th Woolf Award winner, Elliott follows in the footsteps of most of the greatest riders of the modern era.The Woolf Award Trophy, a replica of the life-sized statue of Woolf that adorns Santa Anita’s Paddock Gardens area, will be presented in a Winner’s Circle ceremony in March. Joseph Talamo981281612%37%$420,908 Martin Pedroza789141412%47%$412,888 Victor Espinoza42911621%62%$609,947 TrainerSts1st2nd3rdWin%ITM%Money Won Norberto Arroyo, Jr.71117415%31%$562,035 Stewart Elliott10211121611%38%$527,872 Mark Glatt51911518%49%$387,025 TRIPLE CROWN CONTENDER ROYAL MO BREEZESRobert B. Lewis Stakes winner Royal Mo, one of the West Coast’s leading Triple Crowncontenders, worked six furlongs on Santa Anita’s fast main track Friday morning in 1:15.40 under regular rider Victor Espinoza.Trainer John Shirreffs sent the son of Uncle Mo owned by Jerry and Ann Moss in company with Tiz Adore, who was clocked in 1:17.40.“I’m very happy with the work,” Shirreffs said, adding that there was still no public decision on whether Royal Mo would run in the San Felipe Stakes at Santa Anita on March 11 or the Rebel at Oaklawn Park March 18.The lone certainty at this point is that Royal Mo and the other Triple Crown contender trained by Shirreffs for the Mosses, Sham Stakes winner Gormley, will not race against each other in the immediate future.“The decision on where and when each horse runs won’t be made until we talk with Dottie (John’s wife and racing manager for the Mosses) and the Mosses,” Shirreffs said.NO. ONE POST OF LITTLE CONCERN FOR BETTYS BAMBINOBettys Bambino seeks his sixth straight victory, his fourth stakes win in a row, and his seventh in eight tries on Santa Anita’s downhill turf course at about 6 1/2 furlongs in Saturday’s $100,000 Sensational Star Stakes for California-bred or sired horses.Trainer Peter Eurton is not sweating the fact that Bettys Bambino drew the No. One post position in a field of five entrees that will be reduced to four at post time.“He’s been on the rail before,” Eurton said. “The rider just lets him settle, the field kind of spreads out, and then he goes to the outside. That’s his best place. You try and send him out of the one hole, it’s a silly thing to do.”Acceptance, entered in both the Sensational Star and Sunday’s Tiznow Stakes at one mile on dirt, will scratch from the Sensational Star and run in the Tiznow.“We’re going to go in the mile,” trainer Kenny Black said Friday morning between sips of coffee at Clockers’ Corner. “We didn’t want to hook the other four that are in the Sensational Star. That’s a helluva race.“Outside of Obviously and Om, you’ve got the best downhill horses on the grounds.”Black’s a keen observer on that point. Between them, Ambitious Brew, Bettys Bambino, Forest Chatter and Richards Boy are a combined 18 for 31 over the unique venue, a winning average of better than 58 percent.The Sensational Star, race three of nine: Bettys Bambino, Corey Nakatani, 6-5; Richards Boy, Victor Espinoza, 3-1; Acceptance, Stewart Elliott, 8-1; Ambitious Brew, Mike Smith, 2-1; and Forest Chatter, Flavien Prat, 7-2. FINISH LINES: Gary Stevens is back on horses in the mornings but doesn’t expect to ride in a race for another two weeks. “I’m available from March 4 on but I’ve got calls for the weekend of (Friday) March 10 and 11,” said the Hall of Fame jockey who has recovered from surgery on having his right hip replaced last Dec. 21 . . . Jockey Luis Contreras rides at Santa Anita Saturday but leaves Sunday to ride full time at Oaklawn Park where he will be given first call by Hall of Fame trainer Steve Asmussen. Contreras enjoyed noticeable success under agent Craig O’Bryan at Santa Anita where he has nine wins, 10 seconds and 21 thirds through Monday. “He was a joy to work for,” said O’Bryan . . . Jockey Brice Blanc is approaching a milestone of 1,000 career wins in North America. Blanc has 998 victories in the United States and Canada, and is named on four horses at Santa Anita Friday . . . Chantal Sutherland also is approaching 1,000. She stands at 994 but has no scheduled mounts today . . .Trainer Vladmir Cerin said he is “considering” the Santa Anita Handicap on March 11 for Follow Me Crev, who returned to the races Monday with a rail-skimming victory under Kent Desormeaux after a seven-month absence. The five-year-old Quality Road gelding missed last year’s Big ‘Cap with an injury . . . Abel Tasmin, winner of the Grade I Starlet at Los Alamitos, worked five furlongs Friday for Simon Callaghan who has her ticketed for next Saturday’s Santa Ysabel Stakes and a meeting with super filly Unique Bella . . . Other notable Friday works were recorded by champion Stellar Wind (five furlongs in 1:01.80 for John Sadler); impressive San Vicente winner Iliad (four furlongs under Flavien Prat in 50.20 for Doug O’Neill for the March 11 San Felipe); Silent Bird with Prat aboard for Mark Glatt for the Grade I Triple Bend March 11); multiple graded stakes winner Bal a Bali (seven furlongs for Richard Mandella in 1:26.80); Grade I Gold Cup winner Hard Aces (five furlongs for John Sadler in 1:01.40, breezing) and Grade I Kilroe Mile winner What a View (four furlongs for Kenny Black on the training track in 49.60).  For comprehensive morning workout video, please visit the XBTV.com, “video on demand.”  TVG reporter/host/analysts Christina Blacker and handicapping author James Quinn will be Tom Quigley‘s guests, Saturday and Sunday, 11:20 a.m. in the East Paddock Gardens . . . There was a single winning ticket in Monday’s Pick 6 that paid $109,732.80 purchased through a Maryland hub for $1,880. SANTA ANITA JOCKEYS FALL TO HOLY ANGELS, 26-20                   In a game that went down to the wire, Holy Angels Elementary School defeated Santa Anita’s Jockeys, 26-20, in the 50th annual charity basketball game played between the two squads Thursday night at La Salle High School in Pasadena.Proceeds will benefit the Permanently Disabled Jockeys Fund (PDJF), Holy Angels athletic program and the Eye on Jacob Foundation.The Jockeys led at halftime, 14-13, and trailed by only three points until Holy Angels hit a three-point basket at the buzzer to produce the final score.“It was a lot of fun,” said TVG’s Kurt Hoover, who coached the riders for the 16th consecutive season. “It was close until the final three-point basket.”Said Derek Lawson, agent for jockey Flavien Prat: “It was a wrestling match out there. Nakatani should have been tossed out of the game.”But it was for a worthy cause and all in good fun.The following played in the game and scored (points in parentheses): Kent Desormeaux (five), his son, Josh (four), Corey Nakatani (four), Chester Bonnet (two), Edwin Maldonado (two), Jamie Theriot (two) and Chantal Sutherland (one).Playing but not scoring were agent Nelson Arroyo, Chad Lindsay, Mario Gutierrez,  Gallyn Mitchell, Tiago Pereira, Flavien Prat, Joe Talamo and Jose Verenzuela.On behalf of event organizers Nancy Dollase and Angie Stevens, the Holy Angels Athletics program, the Permanently Disabled Jockeys Fund and the Eye on Jacob Foundation, Santa Anita offers a huge thank you to all sponsors who donated their time and money to such worthy causes:Baltas Racing, Dennis O’Neill, Eclipse Racing, Ruis Racing, Phil D’Amato, Solis/Litt Bloodstock, Bonne Chance Farm, Madeline Auerbach, Desormeaux Racing, Dollase Racing, LNJ Foxwoods, ERJ Racing, KM Racing Enterprise, Inc., Cash Call, Bayern, Little Red Feather Racing Club, Brazilian Friends, West Point Thoroughbreds, Stud RDI, Spendthrift Farm and last but not least, Arrogate. JockeyMts1st2nd3rdWin%ITM%Money Won Flavien Prat15437222824%56%$2,423,166 Tyler Baze16030331719%50%$1,399,786 Santiago Gonzalez899121010%35%$448,752 SANTA ANITA STATISTICS ROYAL MO WORKS FOR SAN FELIPE OR REBELTHE RAIL NO PROBLEM FOR BETTYS BAMBINOELLIOTT WINS THE PRESTIGIOUS WOOLF AWARDBEJARANO RESUMES RIDING NEXT THURSDAYSANTA ANITA RIDERS EDGED IN CHARITY GAMESTEVENS HAS CALLS DURING BIG ‘CAP WEEK FIRST-EVER SANTA ANITA MARDI GRAS SATURDAY MARDI GRAS COMES TO SANTA ANITA SATURDAYThe bayou comes to Santa Anita Saturday for the first-ever Mardi Gras Trackside celebration. Join in on the festivities a few days early and let the good times roll.The $28 package includes Cajun fare courtesy of “Ragin’ Cajun on Wheels” (choice of ½ shrimp or ½ catfish Po’ Boy sandwich with choice of side, or a combo plate of red beans and rice with smoked sausage and Gumbolaya, (a Ragin Cajun on Wheels specialty), live music and Mardi Gras-inspired decorations. BEJARANO TO RESUME RIDING ON MARCH 2Perennial Southern California riding king Rafael Bejarano is scheduled to resume riding at Santa Anita next Thursday after recovering from minor injuries when he was unseated from Eaglemaker in the ninth race on Feb. 18.“He just stayed home and got the (left) knee 100 percent,” said Bejarano’s agent Tora Yamaguchi. “He banged up the knee a little bit in the spill and it was still a little sore. He had to serve a three-day suspension so we figured we might as well take those days at this time. Why come back for one day, Sunday?”Bejarano, a 32-year-old native of Peru, had 18 wins from 99 mounts before his mishap, still good for fourth in the standings right now but well behind leader Flavien Prat at 37. Philip D’Amato611371021%49%$809,080 Jerry Hollendorfer9218111820%51%$1,331,108 Tiago Pereira73107914%36%$303,865 Rafael Bejarano9918151718%51%$983,493 Bob Baffert4296721%52%$884,686 Also, one 12 oz. craft beer, Club House admission, program, tip sheet and seating. – For more info and to purchase your ticket visit: http://www.santaanita.com/events/mardi-gras-at-santa-anita-park/Upcoming Trackside events at the Winter Meet: Feb. 25, Mardi Gras Celebration; March 18, Big ‘Cap Beer & Cider Festival; March 18, St. Patrick’s Day; April 8, Santa Anita Derby Day Extravaganza; May 6, Kentucky Derby Day Celebration; May 13, Tacos y Cervezas; May 20, Preakness Party; May 27, Gold Cup Beer & Sour Festival; and May 27, Belmont Day. Mike Smith37123932%65%$1,192,159 Peter Miller732017627%59%$1,065,155 Richard Baltas8915151417%49%$809,517 Kent Desormeaux9921121021%43%$1,267,401 Doug O’Neill10511221910%50%$1,025,986 William Spawr2192243%62%$264,271last_img read more

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December 29, 2019

Sony exits projector TV arena

first_imgTOKYO – Sony is dropping its money-losing rear-projection TV business worldwide to focus on two flat-panel technologies – liquid crystal display and organic light-emitting diode, the company said Thursday. Sales of rear-projection TVs had been declining recently as LCD TVs gain in popularity and get bigger, Sony Corp. spokesman Shinji Obana said. In October, Sony lowered its global sales forecast for rear-projection TVs – which uses a projector to create images on large screens – to 400,000 from 700,000, which is down from 1.1 million the previous fiscal year. By contrast, Sony expects to sell 10 million LCD TVs this fiscal year through March, up from 6.3 million the previous year. Sony sells 85 percent of its rear-projection TVs in the U.S., and about 10 percent in Europe, Obana said. Production at the three plants that make the rear-projection TVs in Japan, Mexico and Malaysia, will be halted, he said. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! AD Quality Auto 360p 720p 1080p Top articles1/5READ MORECoach Doc Rivers a “fan” from way back of Jazz’s Jordan ClarksonThe decision to abandon rear-projection TVs underlines Sony’s strategy of focusing on LCDs and OLEDs at a time when competition is heating up in flat TVs. In the fiscal half-year through September, Sony lost 60 billion yen ($526.3 million) in its TV operations, partly because of losses tied to rear-projection TVs. Diving prices of LCD TVs also contributed to the red ink, Obana said.last_img read more

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December 9, 2019

What Discovery Means Now

first_imgI am working on my third book right now, and I am spending time jotting down my notes about The Commitment to Explore Change and what “discovery” now means as it pertains to sales.First, in The Lost Art of Closing: Winning the 10 Commitments That Drive Sales, I don’t think I did a good enough job explaining the shift from our discovering something about the client through asking questions to help the client discover something about themselves and their business. This is such a dramatic shift that I believe it deserves much more attention than I gave it. I am going to remedy this, and I am going to be very prescriptive like I was in The Lost Art of Closing.Second, I haven’t ever shared my evolving view about discovery and the process of change. My views have undergone a radical change, and I am clearer on how much our success in helping others produce results is subject to all kinds of factors.We spend so much time getting relatively few people’s opinions without spending enough time with people who are going to be affected by the change that we are recommending. Because we have focused on acquiring the view of a few people, we have a very limited view.We spend too little time actually exploring and building an understanding of what our client is doing and why they are struggling. We are too focused on selling our solution, hen more often than not, there are real changes the client must make to produce the results they need. We are negligent in not trying to understand the root cause of their issues, and that is often what is really necessary for producing the result they need.Look at a deal you are working on now and tell me how much work you have done to understand their competitive strategy and measured it against what is going on in the world right now. I am not suggesting you do a full SWOT analysis on every client, but real discovery means getting a fuller picture of where they are now and whether or not they are keeping pace or lagging behind the constant, accelerating, disruptive change that is the new normal.What about the company’s culture? What impact is this going to have on the ability to produce the results the client needs? Right now, I am watching a company with a fear-driven culture where failure and mistakes are punished, and where there is no candor. It is imploding before my eyes, and the culture is so pervasive that it is preventing the company from saving itself.Yesterday on The Lost Art of Closing Facebook Mastermind Coaching meeting, I shared some of the lenses I use to view individuals and companies. There was a very high level of interest in this discussion, mostly because I don’t often share these lenses, and when I do, it’s usually in a workshop, and I don’t go very deep. This has convinced me to do the work to share this more widely, and it is going to make its way into my third book, which is tentatively titled: The Competitive Displacement Playbook (even though I won’t get to name the book).Think deeply about what you are discovering and helping others discover. See if you can broaden your perspective and identify the real obstacle to change. Essential Reading! Get my 3rd book: Eat Their Lunch “The first ever playbook for B2B salespeople on how to win clients and customers who are already being serviced by your competition.” Buy Nowlast_img read more

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November 27, 2019

Cristiano Ronaldo fined $22K by UEFA for obscene gesture

first_imgLATEST STORIES Trump tells impeachment jokes at annual turkey pardon event Sports Related Videospowered by AdSparcRead Next ‘No evidence’ that American figure skater intended to harm rival MOST READ Juventus’ Cristiano Ronaldo celebrates after scoring his side’s third goal during the Champions League round of 16, 2nd leg, soccer match between Juventus and Atletico Madrid at the Allianz stadium in Turin, Italy, Tuesday, March 12, 2019. (AP Photo/Antonio Calanni)NYON, Switzerland — Cristiano Ronaldo has been fined 20,000 euros ($22,750) by UEFA for making a provocative gesture after Juventus beat Atletico Madrid in the Champions League.UEFA says its disciplinary panel found the Juventus star guilty of improper conduct.ADVERTISEMENT Miguel Romero Polo: Bamboo technology like no other PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss Ronaldo was fined the same sum imposed on Atletico coach Diego Simeone for the same gesture during the round of 16 first-leg game in Spain.Ronaldo scored a hat trick in a 3-0 win in the return leg in Turin to send Juventus to the quarterfinals.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSPalace wants Cayetano’s PHISGOC Foundation probed over corruption chargesSPORTSSingapore latest to raise issue on SEA Games food, logisticsHe celebrated at the final whistle by mimicking Simeone’s gesture.Juventus faces Ajax next month. Private companies step in to help SEA Games hosting View comments Colombia protesters vow new strike after talks hit snag Wintry storm delivers US travel woes before Thanksgiving SEA Games hosting troubles anger Duterte Google Philippines names new country director Don’t miss out on the latest news and information. Bloomberg: US would benefit from more, not fewer, immigrantslast_img read more

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October 28, 2019

3 days agoGuardiola hails ‘incredible’ Man City with five-goal rout of Atalanta

first_imgGuardiola hails ‘incredible’ Man City with five-goal rout of Atalantaby Freddie Taylor3 days agoSend to a friendShare the lovePep Guardiola labelled Manchester City’s 5-1 win over Atalanta as “incredible”.The game was tightly balanced with City holding onto a 2-1 at half-time, thanks to a double from Sergio Aguero.But the Italians couldn’t hold off an avalanche in the second-half, with Raheem Sterling scoring an incredible hat-trick.The only negatives for City on what was a magical night at the Etihad was an injury to Rodri and red-card for Phil Foden.Speaking after the game, Guardiola told BT Sport: “It was a really good result. The way Atalanta played created that. It was man to man all over the stadium, it was not comfortable, we’re not used to playing against these teams.”It was no surprise Atalanta finished third last season in Italy and even this season, they’re playing well so it’s an incredible result. It’s three more points. One more win and we’ll be in the next stage.”Raheem Sterling was brilliant. He could have scored one more. Not just with the ball, without the ball, he helps us a lot.” About the authorFreddie TaylorShare the loveHave your saylast_img read more

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October 23, 2019

NAT Widens FullYear Loss but Bullish on 2018

first_imgzoom Due to volatility in the tanker shipping industry, Bermuda-based Nordic American Tankers (NAT) wrapped up 2017 with a net loss of USD 75.5 million, compared to a loss of USD 4.5 million seen a year earlier.The company’s net loss narrowed to USD 21.9 million in the fourth quarter of 2017 from USD 39.2 million recorded in the corresponding quarter of 2016.NAT said that 4Q 2017 was “an important quarter” with the first major steps in the recapitalization program having been completed.During the quarter, NAT agreed with Ocean Yield ASA the full financing of its three newbuilds to be delivered in June, August and October 2018.In addition, the company raised USD 110 million in new equity in December 2017.NAT also agreed to establish a new credit facility as part of the plan to replace the original credit facility of 2004.Earlier, World Maritime News reported that Herbjørn Hansson, CEO of NAT, expects 2018 to be a better year for the company than 2017, bringing higher earnings and dividend.In its 4Q 2017 report, the company confirmed this view: “We expect the tanker market to turn for the better in 2018.”Currently, NAT’s fleet comprises 33 Suezmaxes, including the three newbuilds, with an aggregate cargo capacity of 33 million barrels of crude oil.last_img read more

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